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TargetTyrosine-protein phosphatase non-receptor type 1
LigandBDBM50045055
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1456270 (CHEMBL3367793)
IC50 31400±n/a nM
Citation Zhi, YGao, LXJin, YTang, CLLi, JYLi, JLong, YQ 4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem22:3670-83 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein phosphatase non-receptor type 1
Name:Tyrosine-protein phosphatase non-receptor type 1
Synonyms:PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:Protein phosphatase
Mol. Mass.:49963.76
Organism:Homo sapiens (Human)
Description:Human recombinant GST-fusion PTP1B (1-435).
Residue:435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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  Blast E-value cutoff:
BDBM50045055
n/a
NameBDBM50045055
Synonyms:CHEMBL3309778
TypeSmall organic molecule
Emp. Form.C27H21F2NO3
Mol. Mass.445.4573
SMILESFc1ccc(COC(=O)c2cn(C3CC3)c3ccc(Cc4ccc(F)cc4)cc3c2=O)cc1
Structure
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