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TargetIntegrase
LigandBDBM50045081
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1457167 (CHEMBL3369753)
IC50 22±n/a nM
Citation Johns, BAKawasuji, TWeatherhead, JGBoros, EEThompson, JBKoble, CSGarvey, EPFoster, SAJeffrey, JLFujiwara, T Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groups. Bioorg Med Chem Lett24:3104-7 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Integrase
Name:Integrase
Synonyms:pol
Type:PROTEIN
Mol. Mass.:32203.43
Organism:Human immunodeficiency virus 1
Description:ChEMBL_106649
Residue:288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50045081
n/a
NameBDBM50045081
Synonyms:CHEMBL3310083
TypeSmall organic molecule
Emp. Form.C23H26FN5O4
Mol. Mass.455.482
SMILESCNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CC(=O)NCCN(C)C)c1=O
Structure
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