Reaction Details |
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Target | Calcium/calmodulin-dependent protein kinase type IV |
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Ligand | BDBM50045370 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1459854 (CHEMBL3367277) |
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IC50 | >30000±n/a nM |
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Citation | Xiao, D; Zhu, X; Sofolarides, M; Degrado, S; Shao, N; Rao, A; Chen, X; Aslanian, R; Fossetta, J; Tian, F; Trivedi, P; Lundell, D; Palani, A Discovery of a novel series of potent MK2 non-ATP competitive inhibitors using 1,2-substituted azoles as cis-amide isosteres. Bioorg Med Chem Lett24:3609-13 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Calcium/calmodulin-dependent protein kinase type IV |
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Name: | Calcium/calmodulin-dependent protein kinase type IV |
Synonyms: | CAM kinase-GR | CAMK | CAMK-GR | CAMK4 | CAMKIV | CaM kinase IV | CaMK IV | Calcium/calmodulin-dependent protein kinase type IV | KCC4_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 51919.87 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1459854 |
Residue: | 473 |
Sequence: | MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV
YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL
VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP
LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP
FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV
TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS
PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA
VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY
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BDBM50045370 |
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n/a |
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Name | BDBM50045370 |
Synonyms: | CHEMBL3314140 |
Type | Small organic molecule |
Emp. Form. | C23H21ClN4O |
Mol. Mass. | 404.892 |
SMILES | Clc1ccc(cc1)-c1ccc(o1)-c1nccn1-c1ccc(cc1)N1CCNCC1 |
Structure |
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