| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2Y purinoceptor 1 |
|---|
| Ligand | BDBM50045598 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1454530 (CHEMBL3365972) |
|---|
| IC50 | 1.1±n/a nM |
|---|
| Citation |  Yang, W; Wang, Y; Lai, A; Qiao, JX; Wang, TC; Hua, J; Price, LA; Shen, H; Chen, XQ; Wong, P; Crain, E; Watson, C; Huang, CS; Seiffert, DA; Rehfuss, R; Wexler, RR; Lam, PY Discovery of 4-aryl-7-hydroxyindoline-based P2Y1 antagonists as novel antiplatelet agents. J Med Chem57:6150-64 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2Y purinoceptor 1 |
|---|
| Name: | P2Y purinoceptor 1 |
|---|
| Synonyms: | ATP receptor | P2RY1 | P2RY1_HUMAN | P2Y purinoceptor 1 (P2Y1) | P2Y1 | Purinergic receptor | Purinergic receptor P2Y1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42090.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P47900 |
|---|
| Residue: | 373 |
|---|
| Sequence: | MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYIL
VFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFG
DAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVV
VAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLI
VRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFND
RVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLN
ILPEFKQNGDTSL
|
|
|
|---|
| BDBM50045598 |
|---|
| n/a |
|---|
| Name | BDBM50045598 |
|---|
| Synonyms: | CHEMBL3314311 | US9540323, 220 | US9540323, example 220 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H24ClF4N3O3 |
|---|
| Mol. Mass. | 585.976 |
|---|
| SMILES | CC1(C)CN(c2c1c(c(F)cc2O)-c1ccc(Cl)cc1)c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
