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TargetIndoleamine 2,3-dioxygenase 1
LigandBDBM50046136
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1458164
IC50 80±n/a nM
Citation Cheng MFHung MSSong JSLin SYLiao FYWu MHHsiao WHsieh CLWu JSChao YSShih CWu SYUeng SH Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors. Bioorg Med Chem Lett 24:3403-6 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Indoleamine 2,3-dioxygenase 1
Name:Indoleamine 2,3-dioxygenase
Synonyms:IDO | IDO-1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase
Type:Enzyme
Mol. Mass.:45330.80
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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  Blast E-value cutoff:
BDBM50046136
n/a
NameBDBM50046136
Synonyms:CHEMBL3310298
TypeSmall organic molecule
Emp. Form.C16H17N3O5S
Mol. Mass.363.388
SMILESCc1cccc(NNS(=O)(=O)c2ccc(cc2)C(=O)NCC(O)=O)c1
Structure
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