Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM50046430 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1449322 (CHEMBL3371468) |
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Ki | 0.110000±n/a nM |
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Citation | Orwat, MJ; Qiao, JX; He, K; Rendina, AR; Luettgen, JM; Rossi, KA; Xin, B; Knabb, RM; Wexler, RR; Lam, PY; Pinto, DJ Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties. Bioorg Med Chem Lett24:3341-5 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50046430 |
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n/a |
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Name | BDBM50046430 |
Synonyms: | CHEMBL3314442 |
Type | Small organic molecule |
Emp. Form. | C26H32N4O4S |
Mol. Mass. | 496.622 |
SMILES | COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)C(C)(C)CN(C)C)S(C)(=O)=O |
Structure |
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