| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein phosphatase 1D |
|---|
| Ligand | BDBM50046668 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1451879 (CHEMBL3362813) |
|---|
| IC50 | <20000±n/a nM |
|---|
| Citation |  Cheeseman, MD; Faisal, A; Rayter, S; Barbeau, OR; Kalusa, A; Westlake, M; Burke, R; Swan, M; van Montfort, R; Linardopoulos, S; Jones, K Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines. Bioorg Med Chem Lett24:3469-74 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein phosphatase 1D |
|---|
| Name: | Protein phosphatase 1D |
|---|
| Synonyms: | PP2C-delta | PPM1D | PPM1D_HUMAN | Protein phosphatase 2C isoform delta | Protein phosphatase magnesium-dependent 1 delta | WIP1 | p53-induced protein phosphatase 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 66695.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1515094 |
|---|
| Residue: | 605 |
|---|
| Sequence: | MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPG
GEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHL
WGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVII
RGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSG
VNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHT
LDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQ
RMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVK
SLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAK
ALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEE
SNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRK
TVCVC
|
|
|
|---|
| BDBM50046668 |
|---|
| n/a |
|---|
| Name | BDBM50046668 |
|---|
| Synonyms: | CHEMBL3314457 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H10N2O2S |
|---|
| Mol. Mass. | 294.328 |
|---|
| SMILES | O=c1[nH]c2ccc(cc2o1)-c1csc(n1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
