| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase |
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| Ligand | BDBM50046827 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1452800 (CHEMBL3365142) |
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| IC50 | 44000±n/a nM |
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| Citation |  Perdih, A; Hrast, M; Barreteau, H; Gobec, S; Wolber, G; Solmajer, T Benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole derivatives as multiple inhibitors of bacterial Mur ligases (MurC-MurF). Bioorg Med Chem22:4124-34 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase |
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| Name: | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase |
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| Synonyms: | JW0083 | MURE_ECOLI | Meso-A2pm-adding enzyme | Meso-diaminopimelate-adding enzyme | MurE (E. coli) | UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase | UDP-MurNAc-tripeptide synthetase | UDP-N-acetylmuramyl-tripeptide synthetase | murE |
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| Type: | Protein |
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| Mol. Mass.: | 53333.42 |
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| Organism: | Escherichia coli UMNK88 (Enterobacteria) |
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| Description: | P22188 |
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| Residue: | 495 |
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| Sequence: | MADRNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGV
AAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGK
TTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPTENTTGSAVDVQHELAGLVDQGATFC
AMEVSSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIIN
ADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIE
SHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAH
TPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEE
PRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLD
YSDRVTVARLLGVIA
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| BDBM50046827 |
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| n/a |
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| Name | BDBM50046827 |
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| Synonyms: | CHEMBL3310467 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H12ClN3O2S |
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| Mol. Mass. | 381.835 |
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| SMILES | Clc1ccc(cc1)N1C(=S)NC(=O)\C(=C\c2cc3ccccc3[nH]2)C1=O |
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| Structure | 
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