Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDNA gyrase subunit B
LigandBDBM50047196
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1454592 (CHEMBL3366704)
IC50<10.0±n/a nM
Citation Basarab, GSHill, PJGarner, CEHull, KGreen, OSherer, BADangel, PBManchester, JIBist, SHauck, SZhou, FUria-Nickelsen, MIllingworth, RAlm, RRooney, MEakin, AE Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). J Med Chem57:6060-82 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA gyrase subunit B
Name:DNA gyrase subunit B
Synonyms:DNA gyrase | DNA gyrase subunit B (DNA gyraseB) | DNA gyrase subunit B (gyrB) | GYRB_STAAU | gyrB
Type:Enzyme Subunit
Mol. Mass.:72530.91
Organism:Staphylococcus aureus
Description:n/a
Residue:644
Sequence:
MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEAL
AGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVS
GGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKAD
GEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELL
NENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRAL
TRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVV
DKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLAD
CSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQ
MITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIA
QPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEH
RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50047196
n/a
NameBDBM50047196
Synonyms:CHEMBL3314562
TypeSmall organic molecule
Emp. Form.C18H21Cl2N5O5S
Mol. Mass.490.361
SMILESCNC(=O)c1sc(nc1C(O)=O)N1CC[C@@H](NC(=O)c2[nH]c(C)c(Cl)c2Cl)[C@H](C1)OC |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: