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TargetDNA Gyrase Subunit B
LigandBDBM50047346
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1454592
IC50<9.8±n/a nM
Citation Basarab GSHill PJGarner CEHull KGreen OSherer BADangel PBManchester JIBist SHauck SZhou FUria-Nickelsen MIllingworth RAlm RRooney MEakin AE Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). J Med Chem 57:6060-82 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA Gyrase Subunit B
Name:DNA gyrase
Synonyms:DNA gyrase subunit B (gyrB)
Type:Enzyme Subunit
Mol. Mass.:72530.91
Organism:Staphylococcus aureus
Description:n/a
Residue:644
Sequence:
MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEAL
AGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVS
GGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKAD
GEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELL
NENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRAL
TRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVV
DKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLAD
CSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQ
MITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIA
QPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEH
RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50047346
n/a
NameBDBM50047346
Synonyms:CHEMBL3314589
TypeSmall organic molecule
Emp. Form.C21H21Cl2N5O4S
Mol. Mass.510.394
SMILESCO[C@H]1CN(CC[C@H]1NC(=O)c1[nH]c(C)c(Cl)c1Cl)c1nc(c(s1)C(O)=O)-c1ccccn1 |r|
Structure
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