Ki Summary

Reaction Details

Report a problem with these data

Target

Calcitonin gene-related peptide type 1 receptor

Ligand

BDBM50184069

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1457286 (CHEMBL3370551)

3.4±n/a nM

Citation

Bell, IM Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine. J Med Chem57:7838-58 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Calcitonin gene-related peptide type 1 receptor

Name:

Calcitonin gene-related peptide type 1 receptor

Synonyms:

CALRL_RAT | Calcitonin-gene-related peptide receptor; CALCRL/RAMP1 | Calcrl | Cgrpr

Type:

PROTEIN

Mol. Mass.:

53330.91

Organism:

Rattus norvegicus

Description:

ChEMBL_1457286

Residue:

464

Sequence:

MMDKKCTLCFLFLLLLNMALIAAESEEGANQTDLGVTRNKIMTAQYECYQKIMQDPIQQG
EGLYCNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGNWFRHPDSNRT
WTNYTLCNNSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNL
FFSFVCNSIVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLLPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKV
AEEVYDYVMHILMHYQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNGFSHSDALRSAS
YTVSTISDVQGYSHDCPTEHLNGKSIQDIENVALKPEKMYDLVM

BDBM50184069

n/a

Name

BDBM50184069

Synonyms:

CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(pyridin-4-yl)piperazin-1-yl)hexan-2-ylamino)-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxamide | N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide | OLCEGEPANT

Type

Small organic molecule

Emp. Form.

C38H47Br2N9O5

Mol. Mass.

869.645

SMILES

NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)C(=O)N1CCN(CC1)c1ccncc1

Structure