| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase |
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| Ligand | BDBM50047418 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1450204 (CHEMBL3375767) |
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| IC50 | 3.4±n/a nM |
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| Citation |  McCoull, W; Barton, P; Brown, AJ; Bowker, SS; Cameron, J; Clarke, DS; Davies, RD; Dossetter, AG; Ertan, A; Fenwick, M; Green, C; Holmes, JL; Martin, N; Masters, D; Moore, JE; Newcombe, NJ; Newton, C; Pointon, H; Robb, GR; Sheldon, C; Stokes, S; Morgan, D Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists. J Med Chem57:6128-40 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase |
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| Name: | Histone deacetylase |
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| Synonyms: | Hdac5 | Hdac5 protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34754.92 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_104809 |
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| Residue: | 328 |
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| Sequence: | MHSSSAVRMAVGCLVELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKL
LQQKLSVGKVLIVDWDIHHGNGTQQAFYDDPSVLYISLHRYDNGNFFPGSGAPEEVGGGP
GVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLG
GYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAV
LQQKPSINAVATLEKVIEIQSKHWSCVQRFATGLGCSLREAQTGEKEEAETVSAMALLSM
GAEQAQAAATQEHSPRPAEEPMEQEPAL
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| BDBM50047418 |
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| n/a |
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| Name | BDBM50047418 |
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| Synonyms: | CHEMBL3319223 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H33ClN6O5S2 |
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| Mol. Mass. | 621.171 |
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| SMILES | CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(ccc4Cl)N4CCOCC4)sc3c2)CC1 |
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| Structure | 
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