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TargetEnoyl-ACP Reductase (InhA)
LigandBDBM50370232
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1451023
IC50 30±n/a nM
Citation Bellale ENaik MV B VAmbady ANarayan ARavishankar SRamachandran VKaur PMcLaughlin RWhiteaker JMorayya SGuptha SSharma SRaichurkar AAwasthy DAchar VVachaspati PBandodkar BPanda MChatterji M Diarylthiazole: an antimycobacterial scaffold potentially targeting PrrB-PrrA two-component system. J Med Chem 57:6572-82 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Enoyl-ACP Reductase (InhA)
Name:Enoyl-ACP Reductase (InhA)
Synonyms:Enoyl-[acyl-carrier-protein] reductase | NADH-dependent enoyl-ACP reductase
Type:Enzyme
Mol. Mass.:28526.00
Organism:Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:P9WGR1
Residue:269
Sequence:
MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL
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  Blast E-value cutoff:
BDBM50370232
n/a
NameBDBM50370232
Synonyms:BA-41166E | L-5103 | RIFAMPIN | Rifadin | Rifampicin
TypeSmall organic molecule
Emp. Form.C43H58N4O12
Mol. Mass.822.9402
SMILESCO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c(O)c(\C=N\N4CCN(C)CC4)c(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C |r,c:33,t:3,35|
Structure
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