Ki Summary

Reaction Details

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Target

Enoyl-[acyl-carrier-protein] reductase [NADH]

Ligand

BDBM50370232

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1451023 (CHEMBL3366098)

IC50

30±n/a nM

Citation

Bellale, E; Naik, M; V B, V; Ambady, A; Narayan, A; Ravishankar, S; Ramachandran, V; Kaur, P; McLaughlin, R; Whiteaker, J; Morayya, S; Guptha, S; Sharma, S; Raichurkar, A; Awasthy, D; Achar, V; Vachaspati, P; Bandodkar, B; Panda, M; Chatterji, M Diarylthiazole: an antimycobacterial scaffold potentially targeting PrrB-PrrA two-component system. J Med Chem57:6572-82 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Enoyl-[acyl-carrier-protein] reductase [NADH]

Name:

Enoyl-[acyl-carrier-protein] reductase [NADH]

Synonyms:

Type:

Enzyme

Mol. Mass.:

28526.00

Organism:

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Description:

P9WGR1

Residue:

269

Sequence:

MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL

BDBM50370232

n/a

Name

BDBM50370232

Synonyms:

BA-41166E | L-5103 | RIFAMPIN | Rifadin | Rifampicin

Type

Small organic molecule

Emp. Form.

C43H58N4O12

Mol. Mass.

822.9402

SMILES

CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c(O)c(\C=N\N4CCN(C)CC4)c(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C |r,c:33,t:3,35|

Structure