| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50047973 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1452866 (CHEMBL3365883) |
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| Temperature | 298.15±n/a K |
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| IC50 | 4100±n/a nM |
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| Comments | extracted |
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| Citation |  Valente, S; Trisciuoglio, D; De Luca, T; Nebbioso, A; Labella, D; Lenoci, A; Bigogno, C; Dondio, G; Miceli, M; Brosch, G; Del Bufalo, D; Altucci, L; Mai, A 1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells. J Med Chem57:6259-65 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50047973 |
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| n/a |
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| Name | BDBM50047973 |
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| Synonyms: | CHEMBL3314867 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H24N4O2 |
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| Mol. Mass. | 460.5265 |
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| SMILES | Nc1ccccc1NC(=O)\C=C\c1ccc(Cc2nnc(Cc3cccc4ccccc34)o2)cc1 |
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| Structure | 
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