| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Maternal embryonic leucine zipper kinase |
|---|
| Ligand | BDBM50048357 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1446772 (CHEMBL3381087) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Casale, E; Amboldi, N; Brasca, MG; Caronni, D; Colombo, N; Dalvit, C; Felder, ER; Fogliatto, G; Galvani, A; Isacchi, A; Polucci, P; Riceputi, L; Sola, F; Visco, C; Zuccotto, F; Casuscelli, F Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors. Bioorg Med Chem22:4135-50 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Maternal embryonic leucine zipper kinase |
|---|
| Name: | Maternal embryonic leucine zipper kinase |
|---|
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 74665.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q14680 |
|---|
| Residue: | 651 |
|---|
| Sequence: | MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
|
|
|
|---|
| BDBM50048357 |
|---|
| n/a |
|---|
| Name | BDBM50048357 |
|---|
| Synonyms: | CHEMBL3309990 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H12FN5O2 |
|---|
| Mol. Mass. | 337.3079 |
|---|
| SMILES | Nc1nc2c3c(F)cccc3nc(Cc3ccc4OCOc4c3)n2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
