| Reaction Details |
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 | Report a problem with these data |
| Target | Urotensin II receptor |
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| Ligand | BDBM50048704 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1451066 |
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| Ki | 12±n/a nM |
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| Citation |  Carotenuto A; Auriemma L; Merlino F; Yousif AM; Marasco D; Limatola A; Campiglia P; Gomez-Monterrey I; Santicioli P; Meini S; Maggi CA; Novellino E; Grieco P Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. J Med Chem 57:5965-74 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urotensin II receptor |
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| Name: | Urotensin II receptor |
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| Synonyms: | G-protein coupled receptor 14 | UR-II-R | Urotensin-II |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42159.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Urotensin-II UTS2R HUMAN::Q9UKP6 |
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| Residue: | 389 |
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| Sequence: | MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSA
MGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGD
VGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLL
TLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRR
SQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLT
TCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLS
SCSPQPTDSLVLAPAAPARPAPEGPRAPA
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| BDBM50048704 |
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| n/a |
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| Name | BDBM50048704 |
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| Synonyms: | CHEMBL3315151 |
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| Type | Small organic molecule |
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| Emp. Form. | C52H65N11O11S2 |
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| Mol. Mass. | 1084.27 |
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| SMILES | CC(C)[C@H](NC(=O)[C@@H]1CSSC(C)(C)[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(cc2)C#N)C(=O)N1)C(O)=O |r| |
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| Structure | 
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