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TargetKCNQ (Kv7) potassium channel
LigandBDBM50050157
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1457496
IC50>30000±n/a nM
Citation Flaherty DPSimpson DSMiller MMaki BEZou BShi JWu MMcManus OBAubé JLi MGolden JE Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg Med Chem Lett 24:3968-73 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
KCNQ (Kv7) potassium channel
Name:KCNQ (Kv7) potassium channel
Synonyms:KQT-like 2 | Neuroblastoma-specific potassium channel subunit alpha KvLQT2 | Potassium voltage-gated channel subfamily KQT member 2 | Voltage-gated potassium channel subunit Kv7.2
Type:PROTEIN
Mol. Mass.:95883.20
Organism:Homo sapiens (Human)
Description:ChEMBL_1457496
Residue:872
Sequence:
MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG
GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK
SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI
AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF
LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI
GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW
QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP
CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV
PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI
RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT
DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG
AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP
QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN
LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD
TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50050157
n/a
NameBDBM50050157
Synonyms:CHEMBL1310568
TypeSmall organic molecule
Emp. Form.C21H18N2O2
Mol. Mass.330.3798
SMILESCc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Structure
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