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TargetInward rectifier potassium channel 2
LigandBDBM50312105
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1457498 (CHEMBL3367865)
IC50>30000±n/a nM
Citation Flaherty, DPSimpson, DSMiller, MMaki, BEZou, BShi, JWu, MMcManus, OBAubé, JLi, MGolden, JE Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg Med Chem Lett24:3968-73 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Inward rectifier potassium channel 2
Name:Inward rectifier potassium channel 2
Synonyms:Cardiac inward rectifier potassium channel | IRK-1 | IRK1 | Inward rectifier K(+) channel Kir2.1 | KCNJ2 | KCNJ2_HUMAN | Potassium channel, inwardly rectifying subfamily J member 2 | hIRK1
Type:PROTEIN
Mol. Mass.:48281.20
Organism:Homo sapiens (Human)
Description:ChEMBL_1515520
Residue:427
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFIN
VGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGK
ACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVM
AKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEG
EYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEG
MVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARD
LAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRP
LRRESEI
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BDBM50312105
n/a
NameBDBM50312105
Synonyms:2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide | CHEMBL1081188
TypeSmall organic molecule
Emp. Form.C22H20N2O3
Mol. Mass.360.4058
SMILESCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Structure
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