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TargetPolymerase basic protein 2
LigandBDBM50050697
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1458393 (CHEMBL3369823)
Kd 70±n/a nM
Citation Clark, MPLedeboer, MWDavies, IByrn, RAJones, SMPerola, ETsai, AJacobs, MNti-Addae, KBandarage, UKBoyd, MJBethiel, RSCourt, JJDeng, HDuffy, JPDorsch, WAFarmer, LJGao, HGu, WJackson, KJacobs, DHKennedy, JMLedford, BLiang, JMaltais, FMurcko, MWang, TWannamaker, MWBennett, HBLeeman, JRMcNeil, CTaylor, WPMemmott, CJiang, MRijnbrand, RBral, CGermann, UNezami, AZhang, YSalituro, FGBennani, YLCharifson, PS Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2. J Med Chem57:6668-78 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Polymerase basic protein 2
Name:Polymerase basic protein 2
Synonyms:PB2 | PB2_I34A1 | Polymerase basic protein 2 | RNA-directed RNA polymerase subunit P3
Type:PROTEIN
Mol. Mass.:86120.80
Organism:Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
Description:ChEMBL_109460
Residue:759
Sequence:
MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITAD
KRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPITNTVHYPKIYKTYFE
RVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSE
SQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCW
EQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGIRMVDILRQ
NPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGY
EEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNF
VNRANQRLNPMHQLLRHFQKDAKVLFQNWGVEPIDNVMGMIGILPDMTPSIEMSMRGVRI
SKMGVDEYSSTERVVVSIDRFLRIRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEIN
GPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLF
QQMRDVLGTFDTAQIIKLLPFAAAPPKQSRMQFSSFTVNVRGSGMRILVRGNSPVFNYNK
ATKRLTVLGKDAGTLTEDPDEGTAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGE
KANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
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  Blast E-value cutoff:
BDBM50050697
n/a
NameBDBM50050697
Synonyms:CHEMBL3317982
TypeSmall organic molecule
Emp. Form.C20H22ClFN6O2
Mol. Mass.432.879
SMILESCOCC(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r|
Structure
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