Reaction Details |
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Target | Polymerase basic protein 2 |
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Ligand | BDBM50050757 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1458393 (CHEMBL3369823) |
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Kd | 90±n/a nM |
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Citation | Clark, MP; Ledeboer, MW; Davies, I; Byrn, RA; Jones, SM; Perola, E; Tsai, A; Jacobs, M; Nti-Addae, K; Bandarage, UK; Boyd, MJ; Bethiel, RS; Court, JJ; Deng, H; Duffy, JP; Dorsch, WA; Farmer, LJ; Gao, H; Gu, W; Jackson, K; Jacobs, DH; Kennedy, JM; Ledford, B; Liang, J; Maltais, F; Murcko, M; Wang, T; Wannamaker, MW; Bennett, HB; Leeman, JR; McNeil, C; Taylor, WP; Memmott, C; Jiang, M; Rijnbrand, R; Bral, C; Germann, U; Nezami, A; Zhang, Y; Salituro, FG; Bennani, YL; Charifson, PS Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2. J Med Chem57:6668-78 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polymerase basic protein 2 |
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Name: | Polymerase basic protein 2 |
Synonyms: | PB2 | PB2_I34A1 | Polymerase basic protein 2 | RNA-directed RNA polymerase subunit P3 |
Type: | PROTEIN |
Mol. Mass.: | 86120.80 |
Organism: | Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) |
Description: | ChEMBL_109460 |
Residue: | 759 |
Sequence: | MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITAD
KRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPITNTVHYPKIYKTYFE
RVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSE
SQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCW
EQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGIRMVDILRQ
NPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGY
EEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNF
VNRANQRLNPMHQLLRHFQKDAKVLFQNWGVEPIDNVMGMIGILPDMTPSIEMSMRGVRI
SKMGVDEYSSTERVVVSIDRFLRIRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEIN
GPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLF
QQMRDVLGTFDTAQIIKLLPFAAAPPKQSRMQFSSFTVNVRGSGMRILVRGNSPVFNYNK
ATKRLTVLGKDAGTLTEDPDEGTAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGE
KANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
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BDBM50050757 |
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n/a |
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Name | BDBM50050757 |
Synonyms: | CHEMBL3317978 |
Type | Small organic molecule |
Emp. Form. | C17H18ClFN6 |
Mol. Mass. | 360.816 |
SMILES | N[C@H]1CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| |
Structure |
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