| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
|---|
| Ligand | BDBM50050839 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1459255 (CHEMBL3367485) |
|---|
| Ki | 177±n/a nM |
|---|
| Citation |  De Monte, C; Carradori, S; Secci, D; D'Ascenzio, M; Vullo, D; Ceruso, M; Supuran, CT Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives. Eur J Med Chem84:240-6 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 12 |
|---|
| Name: | Carbonic anhydrase 12 |
|---|
| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 39456.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Catalytic domain of human cloned isozyme was used in the assay |
|---|
| Residue: | 354 |
|---|
| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
|
|
|
|---|
| BDBM50050839 |
|---|
| n/a |
|---|
| Name | BDBM50050839 |
|---|
| Synonyms: | CHEMBL3322446 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H10N2O6S |
|---|
| Mol. Mass. | 298.272 |
|---|
| SMILES | CC1=CC(=O)N(Cc2cccc(c2)[N+]([O-])=O)S(=O)(=O)O1 |t:1| |
|---|
| Structure | 
|
|---|
Search and Browse
