Reaction Details |
| Report a problem with these data |
Target | Carbonic anhydrase 12 |
---|
Ligand | BDBM50050838 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1459255 (CHEMBL3367485) |
---|
Ki | 134±n/a nM |
---|
Citation | De Monte, C; Carradori, S; Secci, D; D'Ascenzio, M; Vullo, D; Ceruso, M; Supuran, CT Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives. Eur J Med Chem84:240-6 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Carbonic anhydrase 12 |
---|
Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
|
|
|
BDBM50050838 |
---|
n/a |
---|
Name | BDBM50050838 |
Synonyms: | CHEMBL3322447 |
Type | Small organic molecule |
Emp. Form. | C11H10N2O6S |
Mol. Mass. | 298.272 |
SMILES | CC1=CC(OCc2cccc(c2)[N+]([O-])=O)=NS(=O)(=O)O1 |c:15,t:1| |
Structure |
|