| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Yes |
|---|
| Ligand | BDBM50050847 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1459272 (CHEMBL3367502) |
|---|
| IC50 | 7950±n/a nM |
|---|
| Citation |  Defaux, J; Antoine, M; Logé, C; Le Borgne, M; Schuster, T; Seipelt, I; Aicher, B; Teifel, M; Günther, E; Gerlach, M; Marchand, P Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells. Bioorg Med Chem Lett24:3748-52 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Yes |
|---|
| Name: | Tyrosine-protein kinase Yes |
|---|
| Synonyms: | Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 60801.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P07947 |
|---|
| Residue: | 543 |
|---|
| Sequence: | MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT
PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI
INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG
IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL
KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE
VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG
ENL
|
|
|
|---|
| BDBM50050847 |
|---|
| n/a |
|---|
| Name | BDBM50050847 |
|---|
| Synonyms: | CHEMBL3318027 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H20N6O |
|---|
| Mol. Mass. | 324.3803 |
|---|
| SMILES | Cn1cc(cn1)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
