| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor gamma |
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| Ligand | BDBM24560 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1460054 (CHEMBL3368588) |
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| EC50 | 3600±n/a nM |
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| Citation |  Lamers, C; Dittrich, M; Steri, R; Proschak, E; Schubert-Zsilavecz, M Molecular determinants for improved activity at PPARa: structure-activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARa. Bioorg Med Chem Lett24:4048-52 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor gamma |
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| Name: | Peroxisome proliferator-activated receptor gamma |
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| Synonyms: | NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2 |
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| Type: | Nuclear Receptor |
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| Mol. Mass.: | 57613.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37231 |
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| Residue: | 505 |
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| Sequence: | MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
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| BDBM24560 |
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| n/a |
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| Name | BDBM24560 |
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| Synonyms: | 2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl}sulfanyl)octanoic acid | CHEMBL518038 | Pirinixic acid-based compound, 6a |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26ClN3O2S |
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| Mol. Mass. | 407.957 |
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| SMILES | CCCCCCC(Sc1nc(Cl)cc(Nc2cccc(C)c2C)n1)C(O)=O |
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| Structure | 
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