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TargetCarbonic anhydrase 12
LigandBDBM50050918
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1460064 (CHEMBL3368598)
Ki 6.3±n/a nM
Citation Chegaev, KLazzarato, LTamboli, YBoschi, DBlangetti, MScozzafava, ACarta, FMasini, EFruttero, RSupuran, CTGasco, A Furazan and furoxan sulfonamides are stronga-carbonic anhydrase inhibitors and potential antiglaucoma agents. Bioorg Med Chem22:3913-21 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 12
Name:Carbonic anhydrase 12
Synonyms:CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:Enzyme
Mol. Mass.:39456.00
Organism:Homo sapiens (Human)
Description:Catalytic domain of human cloned isozyme was used in the assay
Residue:354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50050918
n/a
NameBDBM50050918
Synonyms:CHEMBL3309368
TypeSmall organic molecule
Emp. Form.C14H11N3O5S
Mol. Mass.333.319
SMILESNS(=O)(=O)c1ccc(cc1)-c1c(Oc2ccccc2)no[n+]1[O-]
Structure
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