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TargetN-lysine methyltransferase KMT5A
LigandBDBM50051128
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1450359 (CHEMBL3378196)
IC50 34000±n/a nM
Citation Ma, AYu, WLi, FBleich, RMHerold, JMButler, KVNorris, JLKorboukh, VTripathy, AJanzen, WPArrowsmith, CHFrye, SVVedadi, MBrown, PJJin, J Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem57:6822-33 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
N-lysine methyltransferase KMT5A
Name:N-lysine methyltransferase KMT5A
Synonyms:KMT5A | KMT5A_HUMAN | N-lysine methyltransferase SETD8 | PRSET7 | SET domain-containing protein 8 (SetD8) | SET07 | SET8 | SETD8
Type:Enzyme
Mol. Mass.:42919.11
Organism:Homo sapiens (Human)
Description:Q9NQR1
Residue:393
Sequence:
MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAA
AAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHH
EVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPK
TPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQ
SEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKRE
ALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLI
LIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
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  Blast E-value cutoff:
BDBM50051128
n/a
NameBDBM50051128
Synonyms:CHEMBL3318296
TypeSmall organic molecule
Emp. Form.C26H42N6O2
Mol. Mass.470.6507
SMILESCOc1cc2nc(nc(NCCCCCN3CCN(CC3)C(C)C)c2cc1OC)N1CCCC1
Structure
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