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TargetN-lysine methyltransferase KMT5A
LigandBDBM50051117
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1450360 (CHEMBL3378197)
Kd 18300±n/a nM
Citation Ma, AYu, WLi, FBleich, RMHerold, JMButler, KVNorris, JLKorboukh, VTripathy, AJanzen, WPArrowsmith, CHFrye, SVVedadi, MBrown, PJJin, J Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem57:6822-33 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
N-lysine methyltransferase KMT5A
Name:N-lysine methyltransferase KMT5A
Synonyms:KMT5A | KMT5A_HUMAN | N-lysine methyltransferase SETD8 | PRSET7 | SET domain-containing protein 8 (SetD8) | SET07 | SET8 | SETD8
Type:Enzyme
Mol. Mass.:42919.11
Organism:Homo sapiens (Human)
Description:Q9NQR1
Residue:393
Sequence:
MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAA
AAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHH
EVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPK
TPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQ
SEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKRE
ALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLI
LIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50051117
n/a
NameBDBM50051117
Synonyms:CHEMBL3318285
TypeSmall organic molecule
Emp. Form.C23H35N5O2
Mol. Mass.413.5563
SMILESCOc1cc2nc(nc(NCCCCCN3CCCC3)c2cc1OC)N1CCCC1
Structure
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