| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase SUV39H2 |
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| Ligand | BDBM50051117 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1450368 (CHEMBL3378205) |
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| IC50 | >100000±n/a nM |
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| Citation |  Ma, A; Yu, W; Li, F; Bleich, RM; Herold, JM; Butler, KV; Norris, JL; Korboukh, V; Tripathy, A; Janzen, WP; Arrowsmith, CH; Frye, SV; Vedadi, M; Brown, PJ; Jin, J Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem57:6822-33 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase SUV39H2 |
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| Name: | Histone-lysine N-methyltransferase SUV39H2 |
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| Synonyms: | H3-K9-HMTase 2 | Histone H3-K9 methyltransferase 2 | Histone-lysine N-methyltransferase SUV39H2 | Histone-lysine N-methyltransferase SUV39H2 (Suv39H2) | KMT1B | Lysine N-methyltransferase 1B | SUV39H2 | SUV92_HUMAN | Su(var)3-9 homolog 2 | Suppressor of variegation 3-9 homolog 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 46692.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H5I1 |
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| Residue: | 410 |
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| Sequence: | MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKD
MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK
PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG
ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP
NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK
GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR
TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN
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| BDBM50051117 |
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| n/a |
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| Name | BDBM50051117 |
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| Synonyms: | CHEMBL3318285 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H35N5O2 |
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| Mol. Mass. | 413.5563 |
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| SMILES | COc1cc2nc(nc(NCCCCCN3CCCC3)c2cc1OC)N1CCCC1 |
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| Structure | 
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