| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 3 [N508S] |
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| Ligand | BDBM50051117 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1450370 (CHEMBL3378207) |
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| IC50 | >100000±n/a nM |
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| Citation |  Ma, A; Yu, W; Li, F; Bleich, RM; Herold, JM; Butler, KV; Norris, JL; Korboukh, V; Tripathy, A; Janzen, WP; Arrowsmith, CH; Frye, SV; Vedadi, M; Brown, PJ; Jin, J Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem57:6822-33 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 3 [N508S] |
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| Name: | Protein arginine N-methyltransferase 3 [N508S] |
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| Synonyms: | ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3 | Protein arginine N-methyltransferase 3 (PRMT3) |
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| Type: | Protein |
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| Mol. Mass.: | 59859.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60678[N508S] |
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| Residue: | 531 |
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| Sequence: | MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSA
EETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEY
LKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAR
EDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRT
ESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLN
KLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYP
DICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIK
HIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHW
KQTVFLLEKPFSVKAGEALKGKVTVHKSKKDPRSLTVTLTLNNSTQTYGLQ
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| BDBM50051117 |
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| n/a |
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| Name | BDBM50051117 |
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| Synonyms: | CHEMBL3318285 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H35N5O2 |
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| Mol. Mass. | 413.5563 |
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| SMILES | COc1cc2nc(nc(NCCCCCN3CCCC3)c2cc1OC)N1CCCC1 |
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| Structure | 
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