Reaction Details |
| Report a problem with these data |
Target | Protein arginine N-methyltransferase 1 [11-371] |
---|
Ligand | BDBM50051117 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1450372 (CHEMBL3378209) |
---|
IC50 | >100000±n/a nM |
---|
Citation | Ma, A; Yu, W; Li, F; Bleich, RM; Herold, JM; Butler, KV; Norris, JL; Korboukh, V; Tripathy, A; Janzen, WP; Arrowsmith, CH; Frye, SV; Vedadi, M; Brown, PJ; Jin, J Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem57:6822-33 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Protein arginine N-methyltransferase 1 [11-371] |
---|
Name: | Protein arginine N-methyltransferase 1 [11-371] |
Synonyms: | ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1 |
Type: | Protein |
Mol. Mass.: | 41506.52 |
Organism: | Homo sapiens (Human) |
Description: | Q99873[11-371] |
Residue: | 361 |
Sequence: | MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDE
VRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIV
KANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGL
IFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNAC
LIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYT
HWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRM
R
|
|
|
BDBM50051117 |
---|
n/a |
---|
Name | BDBM50051117 |
Synonyms: | CHEMBL3318285 |
Type | Small organic molecule |
Emp. Form. | C23H35N5O2 |
Mol. Mass. | 413.5563 |
SMILES | COc1cc2nc(nc(NCCCCCN3CCCC3)c2cc1OC)N1CCCC1 |
Structure |
|