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TargetMalate dehydrogenase cytoplasmic
LigandBDBM50052254
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1456624
IC50>100000±n/a nM
Citation Dragovich PSFauber BPBoggs JChen JCorson LBDing CZEigenbrot CGe HGiannetti AMHunsaker TLabadie SLi CLiu YLiu YMa SMalek SPeterson DPitts KEPurkey HERobarge KSalphati LSideris SUltsch MVanderPorten EWang JWei BXu QYen IYue QZhang HZhang XZhou A Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett 24:3764-71 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Malate dehydrogenase cytoplasmic
Name:Malate dehydrogenase cytoplasmic
Synonyms:Cytosolic malate dehydrogenase | Malate dehydrogenase, cytoplasmic
Type:PROTEIN
Mol. Mass.:36427.72
Organism:Homo sapiens (Human)
Description:ChEMBL_1456624
Residue:334
Sequence:
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKN
VIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50052254
n/a
NameBDBM50052254
Synonyms:2',6'-dichloro-4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,1'-biphenyl]-3(2H)-one (3) | CHEMBL3318469
TypeSmall organic molecule
Emp. Form.C18H13Cl3O2S
Mol. Mass.399.719
SMILESOC1=C(Sc2ccccc2Cl)C(=O)CC(C1)c1c(Cl)cccc1Cl |c:1|
Structure
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