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TargetMalate dehydrogenase, cytoplasmic
LigandBDBM50052254
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1456624 (CHEMBL3370224)
IC50>100000±n/a nM
Citation Dragovich, PSFauber, BPBoggs, JChen, JCorson, LBDing, CZEigenbrot, CGe, HGiannetti, AMHunsaker, TLabadie, SLi, CLiu, YLiu, YMa, SMalek, SPeterson, DPitts, KEPurkey, HERobarge, KSalphati, LSideris, SUltsch, MVanderPorten, EWang, JWei, BXu, QYen, IYue, QZhang, HZhang, XZhou, A Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett24:3764-71 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Malate dehydrogenase, cytoplasmic
Name:Malate dehydrogenase, cytoplasmic
Synonyms:Cytosolic malate dehydrogenase | MDH1 | MDHA | MDHC_HUMAN | Malate dehydrogenase cytoplasmic | Malate dehydrogenase, cytoplasmic
Type:PROTEIN
Mol. Mass.:36427.72
Organism:Homo sapiens (Human)
Description:ChEMBL_1456624
Residue:334
Sequence:
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKN
VIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50052254
n/a
NameBDBM50052254
Synonyms:2',6'-dichloro-4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,1'-biphenyl]-3(2H)-one (3) | CHEMBL3318469
TypeSmall organic molecule
Emp. Form.C18H13Cl3O2S
Mol. Mass.399.719
SMILESOC1=C(Sc2ccccc2Cl)C(=O)CC(C1)c1c(Cl)cccc1Cl |c:1|
Structure
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