| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
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| Ligand | BDBM50053260 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1458470 (CHEMBL3370356) |
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| IC50 | 16±n/a nM |
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| Citation |  Song, P; Peng, P; Han, M; Cao, X; Ma, X; Liu, T; Zhou, Y; Hu, Y Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors. Bioorg Med Chem22:4882-92 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk1 |
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| Name: | Serine/threonine-protein kinase Chk1 |
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| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54443.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_166295192 |
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| Residue: | 476 |
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| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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| BDBM50053260 |
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| n/a |
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| Name | BDBM50053260 |
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| Synonyms: | CHEMBL3330132 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N5OS |
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| Mol. Mass. | 365.452 |
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| SMILES | O=c1[nH]c2sccc2c(NC2CCCNC2)c1-c1nc2ccccc2[nH]1 |
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| Structure | 
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