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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Aurora kinase A | ||
| Ligand | BDBM50053256 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1458473 (CHEMBL3370359) | ||
| IC50 | >10000±n/a nM | ||
| Citation |  Song, P; Peng, P; Han, M; Cao, X; Ma, X; Liu, T; Zhou, Y; Hu, Y Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors. Bioorg Med Chem22:4882-92 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Aurora kinase A | |||
| Name: | Aurora kinase A | ||
| Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 45830.98 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O14965 | ||
| Residue: | 403 | ||
| Sequence: |
| ||
| BDBM50053256 | |||
| n/a | |||
| Name | BDBM50053256 | ||
| Synonyms: | CHEMBL3330136 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H21N5OS | ||
| Mol. Mass. | 391.489 | ||
| SMILES | O=c1[nH]c2sccc2c(NC2CN3CCC2CC3)c1-c1nc2ccccc2[nH]1 |(23.44,-23.73,;22.09,-23,;20.77,-23.8,;19.42,-23.07,;17.97,-23.59,;17.03,-22.37,;17.9,-21.1,;19.38,-21.53,;20.69,-20.72,;20.64,-19.19,;19.29,-18.45,;19.25,-16.91,;17.89,-16.18,;16.58,-16.99,;16.62,-18.53,;17.98,-19.26,;19.02,-17.66,;17.48,-17.66,;22.04,-21.46,;23.35,-20.65,;23.47,-19.11,;24.97,-18.75,;25.7,-17.4,;27.24,-17.35,;28.05,-18.66,;27.32,-20.02,;25.78,-20.06,;24.78,-21.24,)| | ||
| Structure | 
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