Reaction Details |
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Target | Serine/threonine-protein kinase PLK1 |
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Ligand | BDBM50053305 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1459293 (CHEMBL3367523) |
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IC50 | >50000±n/a nM |
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Citation | Laufer, R; Ng, G; Liu, Y; Patel, NK; Edwards, LG; Lang, Y; Li, SW; Feher, M; Awrey, DE; Leung, G; Beletskaya, I; Plotnikova, O; Mason, JM; Hodgson, R; Wei, X; Mao, G; Luo, X; Huang, P; Green, E; Kiarash, R; Lin, DC; Harris-Brandts, M; Ban, F; Nadeem, V; Mak, TW; Pan, GJ; Qiu, W; Chirgadze, NY; Pauls, HW Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides. Bioorg Med Chem22:4968-97 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase PLK1 |
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Name: | Serine/threonine-protein kinase PLK1 |
Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 68277.16 |
Organism: | Homo sapiens (Human) |
Description: | P53350 |
Residue: | 603 |
Sequence: | MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
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BDBM50053305 |
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n/a |
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Name | BDBM50053305 |
Synonyms: | CHEMBL3330409 |
Type | Small organic molecule |
Emp. Form. | C25H27N5O3S |
Mol. Mass. | 477.579 |
SMILES | CCc1ccccc1C(N(C)C)C(=O)Nc1ccc2[nH]nc(-c3cccc(c3)S(N)(=O)=O)c2c1 |
Structure |
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