| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic elongation factor 2 kinase |
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| Ligand | BDBM50053584 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1446963 (CHEMBL3373720) |
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| IC50 | 420±n/a nM |
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| Citation |  Edupuganti, R; Wang, Q; Tavares, CD; Chitjian, CA; Bachman, JL; Ren, P; Anslyn, EV; Dalby, KN Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors. Bioorg Med Chem22:4910-6 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic elongation factor 2 kinase |
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| Name: | Eukaryotic elongation factor 2 kinase |
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| Synonyms: | Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EEF2K | EF2K_HUMAN | Eukaryotic elongation factor 2 kinase (EEF2K) | Eukaryotic elongation factor 2 kinase (eEF-2K) | Serine/threonine-protein kinase EEF2K | eEF-2 kinase | eEF-2K |
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| Type: | Protein |
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| Mol. Mass.: | 82116.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 725 |
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| Sequence: | MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYY
SNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAV
TGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDV
YFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYN
SNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNL
GVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSP
QVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDN
MASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGR
VCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFC
EKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDY
LLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQ
DEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAW
AQMEE
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| BDBM50053584 |
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| n/a |
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| Name | BDBM50053584 |
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| Synonyms: | CHEMBL1977874 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15N5O3 |
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| Mol. Mass. | 289.2899 |
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| SMILES | CCn1c(=O)n(C2CC2)c2nc(N)c(cc2c1=O)C(N)=O |
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| Structure | 
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