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Reaction Details
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TargetHexokinase-4
LigandBDBM50053977
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1455572 (CHEMBL3364949)
IC50 17±n/a nM
Citation Hong, FTNorman, MHAshton, KSBartberger, MDChen, JChmait, SCupples, RFotsch, CJordan, SRLloyd, DJSivits, GTadesse, SHale, CSt Jean, DJ Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket. J Med Chem57:5949-64 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hexokinase-4
Name:Hexokinase-4
Synonyms:GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:Enzyme
Mol. Mass.:52175.81
Organism:Homo sapiens (Human)
Description:P35557
Residue:465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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  Blast E-value cutoff:
BDBM50053977
n/a
NameBDBM50053977
Synonyms:CHEMBL3319555
TypeSmall organic molecule
Emp. Form.C23H22F6N6O4S
Mol. Mass.592.514
SMILESCOc1cncc(c1)-c1cc(cnc1N1CCN(CC1)S(=O)(=O)c1ccc(N)nc1)C(O)(C(F)(F)F)C(F)(F)F
Structure
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