| Reaction Details |
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 | Report a problem with these data |
| Target | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 |
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| Ligand | BDBM50054344 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1458325 (CHEMBL3369287) |
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| IC50 | 1300±n/a nM |
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| Citation |  Zeng, LF; Zhang, RY; Yu, ZH; Li, S; Wu, L; Gunawan, AM; Lane, BS; Mali, RS; Li, X; Chan, RJ; Kapur, R; Wells, CD; Zhang, ZY Therapeutic potential of targeting the oncogenic SHP2 phosphatase. J Med Chem57:6594-609 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA polymerase II subunit A C-terminal domain phosphatase SSU72 |
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| Name: | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 |
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| Synonyms: | CTD phosphatase SSU72 | PNAS-120 | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 | SSU72 | SSU72_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 22567.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NP77 |
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| Residue: | 194 |
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| Sequence: | MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTT
YDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVV
EDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFE
EKSGRTFLHTVCFY
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| BDBM50054344 |
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| n/a |
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| Name | BDBM50054344 |
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| Synonyms: | CHEMBL3319356 | US9522881, 11a-1 L97M74 | US9844535, ID 11a-1 L97M74 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H20IN3O5S |
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| Mol. Mass. | 637.445 |
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| SMILES | Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2ccc(cc2)-c2ccsc2)c1 |
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| Structure | 
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