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TargetSodium-dependent noradrenaline transporter
LigandBDBM170440
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1450412 (CHEMBL3379356)
IC50 350±n/a nM
Citation Liu, SZha, CNacro, KHu, MCui, WYang, YLBhatt, USambandam, AIsherwood, MYet, LHerr, MTEbeltoft, SHassler, CFleming, LPechulis, ADPayen-Fornicola, AHolman, NMilanowski, DCotterill, IMozhaev, VKhmelnitsky, YGuzzo, PRSargent, BJMolino, BFOlson, RKing, DLelas, SLi, YWJohnson, KMolski, TOrie, ANg, AHaskell, RClarke, WBertekap, RO'Connell, JLodge, NSinz, MAdams, SZaczek, RMacor, JE Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors. ACS Med Chem Lett5:760-5 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium-dependent noradrenaline transporter
Name:Sodium-dependent noradrenaline transporter
Synonyms:Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:Multi-pass membrane protein
Mol. Mass.:69337.72
Organism:Homo sapiens (Human)
Description:P23975
Residue:617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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BDBM170440
n/a
NameBDBM170440
Synonyms:US9085531, 40
TypeSmall organic molecule
Emp. Form.C18H17NS
Mol. Mass.279.399
SMILESCN1CC(c2ccc3sccc3c2)c2ccccc2C1
Structure
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