| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
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| Ligand | BDBM50054535 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1450411 (CHEMBL3379355) |
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| IC50 | 4.5±n/a nM |
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| Citation |  Liu, S; Zha, C; Nacro, K; Hu, M; Cui, W; Yang, YL; Bhatt, U; Sambandam, A; Isherwood, M; Yet, L; Herr, MT; Ebeltoft, S; Hassler, C; Fleming, L; Pechulis, AD; Payen-Fornicola, A; Holman, N; Milanowski, D; Cotterill, I; Mozhaev, V; Khmelnitsky, Y; Guzzo, PR; Sargent, BJ; Molino, BF; Olson, R; King, D; Lelas, S; Li, YW; Johnson, K; Molski, T; Orie, A; Ng, A; Haskell, R; Clarke, W; Bertekap, R; O'Connell, J; Lodge, N; Sinz, M; Adams, S; Zaczek, R; Macor, JE Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors. ACS Med Chem Lett5:760-5 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent dopamine transporter |
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| Name: | Sodium-dependent dopamine transporter |
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| Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 68497.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q01959 |
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| Residue: | 620 |
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| Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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| BDBM50054535 |
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| n/a |
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| Name | BDBM50054535 |
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| Synonyms: | CHEMBL3323096 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17NS |
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| Mol. Mass. | 279.399 |
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| SMILES | CN1CC(c2ccc3ccsc3c2)c2ccccc2C1 |
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| Structure | 
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