Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50062912 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1450410 (CHEMBL3378814) |
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Ki | >10000±n/a nM |
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Citation | Liu, S; Zha, C; Nacro, K; Hu, M; Cui, W; Yang, YL; Bhatt, U; Sambandam, A; Isherwood, M; Yet, L; Herr, MT; Ebeltoft, S; Hassler, C; Fleming, L; Pechulis, AD; Payen-Fornicola, A; Holman, N; Milanowski, D; Cotterill, I; Mozhaev, V; Khmelnitsky, Y; Guzzo, PR; Sargent, BJ; Molino, BF; Olson, R; King, D; Lelas, S; Li, YW; Johnson, K; Molski, T; Orie, A; Ng, A; Haskell, R; Clarke, W; Bertekap, R; O'Connell, J; Lodge, N; Sinz, M; Adams, S; Zaczek, R; Macor, JE Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors. ACS Med Chem Lett5:760-5 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70322.51 |
Organism: | Homo sapiens (Human) |
Description: | P31645 |
Residue: | 630 |
Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
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BDBM50062912 |
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n/a |
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Name | BDBM50062912 |
Synonyms: | CHEMBL796 | Methylphenidate | alpha-phenyl-2-piperidineacetic acid methyl ester | methyl alpha-phenyl-alpha-(2-piperidyl)acetate | methyl alpha-phenyl-alpha-2-piperidinylacetate | methyl phenidylacetate | methyl phenyl(piperidin-2-yl)acetate | methylphenidan |
Type | Small organic molecule |
Emp. Form. | C14H19NO2 |
Mol. Mass. | 233.3062 |
SMILES | COC(=O)C(C1CCCCN1)c1ccccc1 |
Structure |
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