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TargetRenin
LigandBDBM50054640
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1452194 (CHEMBL3365816)
IC50 1200±n/a nM
Citation Ehara, TIrie, OKosaka, TKanazawa, TBreitenstein, WGrosche, POstermann, NSuzuki, MKawakami, SKonishi, KHitomi, YToyao, AGunji, HCumin, FSchiering, NWagner, TRigel, DFWebb, RLMaibaum, JYokokawa, F Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors. ACS Med Chem Lett5:787-92 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase | REN | RENI_HUMAN
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50054640
n/a
NameBDBM50054640
Synonyms:CHEMBL3318930
TypeSmall organic molecule
Emp. Form.C26H29N3O3S
Mol. Mass.463.592
SMILESCc1ccc(cc1)S(=O)(=O)N[C@@H]1CNC[C@@H](C1)C(=O)NC(c1ccccc1)c1ccccc1 |r|
Structure
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