| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50054781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1453118 (CHEMBL3364416) |
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| IC50 | 0.900000±n/a nM |
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| Citation |  Li, J; Kennedy, LJ; Wang, H; Li, JJ; Walker, SJ; Hong, Z; O'Connor, SP; Nayeem, A; Camac, DM; Morin, PE; Sheriff, S; Wang, M; Harper, T; Golla, R; Seethala, R; Harrity, T; Ponticiello, RP; Morgan, NN; Taylor, JR; Zebo, R; Gordon, DA; Robl, JA Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1). ACS Med Chem Lett5:803-8 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32409.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28845 |
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| Residue: | 292 |
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| Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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| BDBM50054781 |
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| n/a |
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| Name | BDBM50054781 |
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| Synonyms: | CHEMBL3318966 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23ClN4O2 |
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| Mol. Mass. | 446.929 |
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| SMILES | Clc1ccc(cc1)C1(CC1)c1nnc2c(Oc3ccccc3N3CCOCC3)cccn12 |
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| Structure | 
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