Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetKappa-type opioid receptor
LigandBDBM50055067
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1447926
Ki 6.8±n/a nM
Citation Bourgeois CWerfel EGalla FLehmkuhl KTorres-Gómez HSchepmann DKögel BChristoph TStraßburger WEnglberger WSoeberdt MHüwel SGalla HJWünsch B Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted¿-opioid receptor agonists. J Med Chem 57:6845-60 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kappa-type opioid receptor
Name:Kappa-type opioid receptor
Synonyms:Kappa Opioid Receptor | OPIATE Kappa | Opiate Kappa 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:42744.99
Organism:Cavia porcellus (domestic guinea pig)
Description:P41144
Residue:380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50055067
n/a
NameBDBM50055067
Synonyms:CHEMBL3323514
TypeSmall organic molecule
Emp. Form.C28H35Cl2N3O2
Mol. Mass.516.502
SMILESCOc1ccc(CN2CCN(C3C(CCCC23)N2CCCC2)C(=O)Cc2ccc(Cl)c(Cl)c2)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: