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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50055499 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1451317 (CHEMBL3363336) | ||
| IC50 | 1.1±n/a nM | ||
| Citation |  Zhang, W; DeRyckere, D; Hunter, D; Liu, J; Stashko, MA; Minson, KA; Cummings, CT; Lee, M; Glaros, TG; Newton, DL; Sather, S; Zhang, D; Kireev, D; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor. J Med Chem57:7031-41 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
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| BDBM50055499 | |||
| n/a | |||
| Name | BDBM50055499 | ||
| Synonyms: | CHEMBL3326002 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H34N6O4S | ||
| Mol. Mass. | 514.64 | ||
| SMILES | CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:12.11,wD:15.15,(-2.75,-7.06,;-1.43,-6.29,;-.1,-7.06,;1.25,-6.3,;2.58,-7.07,;3.91,-6.3,;3.91,-4.75,;5.24,-3.99,;6.57,-4.75,;8.05,-4.27,;8.96,-5.52,;8.05,-6.78,;8.53,-8.25,;10.03,-8.56,;10.5,-10.03,;9.47,-11.17,;9.94,-12.64,;7.96,-10.85,;7.49,-9.39,;6.57,-6.3,;5.24,-7.07,;8.53,-2.8,;10.04,-2.49,;10.51,-1.03,;9.49,.13,;7.98,-.2,;7.5,-1.67,;9.97,1.58,;8.48,1.99,;9.57,3.09,;11.48,1.89,;12.49,.74,;13.99,1.03,;14.49,2.48,;13.47,3.64,;11.96,3.35,)| | ||
| Structure | 
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