| Reaction Details |
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 | Report a problem with these data |
| Target | Monocarboxylate transporter 1 |
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| Ligand | BDBM22000 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1451367 (CHEMBL3363651) |
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| IC50 | 105±n/a nM |
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| Citation |  Wang, H; Yang, C; Doherty, JR; Roush, WR; Cleveland, JL; Bannister, TD Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. J Med Chem57:7317-24 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monocarboxylate transporter 1 |
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| Name: | Monocarboxylate transporter 1 |
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| Synonyms: | MCT 1 | MCT1 | MOT1_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | Solute carrier family 16 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53956.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1451367 |
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| Residue: | 500 |
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| Sequence: | MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW
ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG
GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI
LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ
EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF
LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA
GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK
YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA
AESPDQKDTDGGPKEEESPV
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| BDBM22000 |
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| n/a |
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| Name | BDBM22000 |
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| Synonyms: | 7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)-1H,2H,6H-pyrrolo[3,4-d]pyridazin-1-one | 7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)-2,6-dihydro-1H-pyrrolo[3,4-d]pyridazin-1-one | Pyrrolo[3,4-d]pyridazin-1-one, 2 |
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| Type | n/a |
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| Emp. Form. | C25H29N3O2S |
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| Mol. Mass. | 435.582 |
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| SMILES | CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3cccc4ccccc34)cc12 |
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| Structure | 
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