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Target5-Hydroxytryptamine receptor 7 (5-HT7)
LigandBDBM50055577
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1453160
Ki 41±n/a nM
Citation Medina RAVázquez-Villa HGómez-Tamayo JCBenhamú BMartín-Fontecha Mde la Fuente TCaltabiano GHedlund PBPardo LLópez-Rodríguez ML The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo. J Med Chem 57:6879-84 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-Hydroxytryptamine receptor 7 (5-HT7)
Name:Serotonin (5-HT) receptor
Synonyms:5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5-hydroxytryptamine receptor 7 | 5HT7 | HTR7
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:53573.08
Organism:Homo sapiens (Human)
Description:P34969
Residue:479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
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BDBM50055577
n/a
NameBDBM50055577
Synonyms:CHEMBL3321796
TypeSmall organic molecule
Emp. Form.C22H32N2O
Mol. Mass.340.5023
SMILES[H][C@]12CCCC[C@]1([H])CN(CCCCCN1C(=O)Cc3ccccc13)CC2 |r|
Structure
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