Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetP2Y purinoceptor 12
LigandBDBM50100188
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1454020 (CHEMBL3367079)
IC50 800±n/a nM
Citation Boldron, CBesse, ABordes, MFTissandié, SYvon, XGau, BBadorc, ARousseaux, TBarré, GMeneyrol, JZech, GNazare, MFossey, VPflieger, AMBonnet-Lignon, SMillet, LBriot, CDol, FHérault, JPSavi, PLassalle, GDelesque, NHerbert, JMBono, F N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist. J Med Chem57:7293-316 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
P2Y purinoceptor 12
Name:P2Y purinoceptor 12
Synonyms:P2Y purinoceptor 12 | P2Y12_RAT | P2ry12 | P2y12 | Purinergic receptor P2Y12
Type:PROTEIN
Mol. Mass.:39068.50
Organism:Rattus norvegicus
Description:ChEMBL_1454020
Residue:343
Sequence:
MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIR
SKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISF
LGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITK
CSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKAPKKRV
NIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCNAENTLFYVKESTLWLTSLNACLD
PFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEGGDPSEETPM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50100188
n/a
NameBDBM50100188
Synonyms:CHEMBL3325632
TypeSmall organic molecule
Emp. Form.C30H34N6O3
Mol. Mass.526.6294
SMILESCCCC(=O)c1cnn(c1C)-c1ccc(NC(=O)c2cn(CC(=O)N[C@H]3CCNC3)c3ccc(C)cc23)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: