| Reaction Details |
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 | Report a problem with these data |
| Target | P2Y purinoceptor 12 |
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| Ligand | BDBM50055843 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1454020 (CHEMBL3367079) |
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| IC50 | 500±n/a nM |
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| Citation |  Boldron, C; Besse, A; Bordes, MF; Tissandié, S; Yvon, X; Gau, B; Badorc, A; Rousseaux, T; Barré, G; Meneyrol, J; Zech, G; Nazare, M; Fossey, V; Pflieger, AM; Bonnet-Lignon, S; Millet, L; Briot, C; Dol, F; Hérault, JP; Savi, P; Lassalle, G; Delesque, N; Herbert, JM; Bono, F N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist. J Med Chem57:7293-316 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2Y purinoceptor 12 |
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| Name: | P2Y purinoceptor 12 |
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| Synonyms: | P2Y purinoceptor 12 | P2Y12_RAT | P2ry12 | P2y12 | Purinergic receptor P2Y12 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39068.50 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1454020 |
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| Residue: | 343 |
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| Sequence: | MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIR
SKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISF
LGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITK
CSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKAPKKRV
NIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCNAENTLFYVKESTLWLTSLNACLD
PFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEGGDPSEETPM
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| BDBM50055843 |
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| n/a |
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| Name | BDBM50055843 |
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| Synonyms: | CHEMBL3325785 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H40N6O4 |
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| Mol. Mass. | 596.7192 |
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| SMILES | [H][C@@]12C[C@@H](O)CN1C[C@H](C)N(C2)C(=O)Cn1cc(C(=O)Nc2ccc(cc2)-n2ncc(C(=O)CCC)c2C)c2cc(C)ccc12 |r| |
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| Structure | 
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