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TargetP2Y purinoceptor 12
LigandBDBM50055819
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1454018 (CHEMBL3367077)
IC50 76±n/a nM
Citation Boldron, CBesse, ABordes, MFTissandié, SYvon, XGau, BBadorc, ARousseaux, TBarré, GMeneyrol, JZech, GNazare, MFossey, VPflieger, AMBonnet-Lignon, SMillet, LBriot, CDol, FHérault, JPSavi, PLassalle, GDelesque, NHerbert, JMBono, F N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist. J Med Chem57:7293-316 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
P2Y purinoceptor 12
Name:P2Y purinoceptor 12
Synonyms:ADP-glucose receptor | ADPG-R | HORK3 | P2RY12 | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | P2Y12_HUMAN | Purinergic receptor P2Y12 | SP1999
Type:Enzyme
Mol. Mass.:39458.48
Organism:Homo sapiens (Human)
Description:Q9H244
Residue:342
Sequence:
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFI
IFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITI
DRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKS
EFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFI
IIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFF
LCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50055819
n/a
NameBDBM50055819
Synonyms:CHEMBL3325663
TypeSmall organic molecule
Emp. Form.C33H38N6O3
Mol. Mass.566.6932
SMILESCCCC(=O)c1cnn(c1C)-c1ccc(NC(=O)c2cn(CC(=O)N3CCN4CCCC4C3)c3ccc(C)cc23)cc1
Structure
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